Santolina chamaecyparissus

Sala AM, Carmen R, Giner M, Manez SR. Anti-phospholipase A2 and anti-inflammatory activity of Santolina chamaecyparissus. Life Sci 2000 66 35-40. 

Other antimicrobial genera from the Anthemideae tribe are the genera Santolina and Senecio. Haggag et al. [92] investigated the chemical composition and antimicrobial activity of the essential oil of Santolina chamaecyparissus L. cultivated in Egypt. In the essential oil. 

Occurrence Usually a mixture of A. and iso-A. is isolated Artemisia oil, obtained from the annual mugwort. (Artemisia annua, Asteraceae) in the flowering season contains a ca. 30% mixture of A. and iso-A. 65% mixtures occur in the essential oil of lavender cotton (Santolina chamaecyparissus, Asteraceae). 

Artemisia ketone (94), derived from IPP and DMAPP in Santolina chamaecyparissus, is asymmetrically labeled that is, the label from IPP is incorporated at much greater levels than that from DMAPP (Allen et al., 1977). A dehydrogenase system rather than a mixed-function oxidase (MFO) system based on cytochrome P-450 appears to be involved in formation of artemisia ketone. 

In cell-free extracts of Artemisia annua and Santolina chamaecyparissus, chrysanthemyl alcohol and its pyrophosphate are incorporated into artemisia ketone and alcohol. Artemisia alcohol (95) is converted into artemisia ketone (94) and tranj-chrysanthemic acid in the preparation from S. chamaecyparissus (Banthorpe et al., 1977a). IPP and DMAPP are incorporated into irregular monoterpenes whereas geranyl and neryl-OPP are not. An enzymatic sulf-hydryl group is involved. 

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