Sample Preparation, Extraction, and Purification

So far most frequently used matrix for lipids [40], Provides positive and negative-ion spectra. The lithium salt of DHB was indicated to be more useful than the free acid when apolar lipids are of interest [44]. 

Useful for the detection of PE in mixtures with PC. In the presence of PNA, PE may be detected as a negative ion, whereas PC is only detected as a positive ion. Enables quantitative analysis of PL [42] but is unstable under high-vacuum conditions [43]. 

Provides comparably good sensitivity when positive-ion spectra of negatively charged PL are recorded. Gives strong background (46j. 

To the present authors knowledge, this is the only available matrix that enables the detection of N hlorinated products (and maybe further oxidized lipids) by MALDI MS (47). 

High sensitivity, low vapor pressure, low acidity, and formation of small crystals. However, strong background below m/z 500 (43) 

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