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Samarium compounds cyclization reactions

Samarium(H) diiodide mediated ketyl radical addition to alkyne results in the formation of an alkene after radical cyclization [95SL277]. Compound 65, a product from one such reaction, has been converted to the carbohydrate portion of miharamycin A, a nucleoside antibiotic. [Pg.20]

The occurrence of the indole subunit is well established within the class of natural products and pharmaceutically active compounds. Recently, the Reissig group developed an impressive procedure for the assembly of highly functionalized in-dolizidine derivatives, highlighting again the versatility of domino reactions [8]. The approach is based on a samarium(II) iodide-mediated radical cyclization terminated by a subsequent alkylation which can be carried out in an intermolecular - as well as in an intramolecular - fashion. Reaction of ketone 3-11 with samarium(II) iodide induced a 6-exo-trig cyclization, furnishing a samarium enolate intermediate... [Pg.224]

See other pages where Samarium compounds cyclization reactions is mentioned: [Pg.640]    [Pg.267]    [Pg.267]    [Pg.150]    [Pg.203]    [Pg.144]    [Pg.649]    [Pg.157]    [Pg.212]    [Pg.1025]    [Pg.143]    [Pg.260]    [Pg.145]    [Pg.154]    [Pg.1099]    [Pg.160]    [Pg.576]    [Pg.115]    [Pg.1279]    [Pg.120]    [Pg.414]    [Pg.210]    [Pg.160]   
See also in sourсe #XX -- [ Pg.762 ]



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Cyclization reactions

Samarium compounds

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