Safe Drugs Are Tried for Many Underserved Indications

Safe Drugs Are Tried for Many UNDERSERVEDIN Die AT IONS 

In this way it is not very surprising that most antiepileptics are also used in pain treatment, that several tricyclic antidepressants are used in pain management, and even that some antiepileptics became mood-stabilizing drugs for bipolar disorder. 

To put it even more simply, drugs can get into the brain if they dissolve in the fats in cell membranes. Charged molecules are usually water-soluble (i.e., are hydrophilic ) and tend not to dissolve in fat (i.e., are lipophobic). Adding charge—making the molecule an ion changes how the molecule is transported in the body. 

Big Pharma recognizes the value of outsourcing projects such as this one cannot do everything in house. Biotech companies rarely remember not to stretch their resources in this way. 

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