Saccharopine, from lysine

Ketoglutarate reductase catalyzes the formation of saccharopine from lysine, which is the first step in a major pathway for lysine catabolism. NADPH and a-ketoglutarate are cofactors in the reaction. 

L-Saccharopine. N-(5-Amino-5-carboxypemyt)-L-glutamic acid -Af-(L-glutar-2-yl)-L-lysine. CnH NjO. mol wt 276.29. C 47.82%. H 7.30%, N 10.14%, O 34.75%. A lysine precursor in the aminoadipic add-lysine pathway in yeast Darling. Larsen, Acta Chem. Scand. IS, 743 (1961) Kjaer. Larsen, ibid. 750 Kuo et al. Biochem Biophys. Res. Commun. 8, 227 (1962) Trupin, Broquist, J. Biol Chem. 240, 2524 (1965) Jones, Broquist, ibid. 241, 3430 sqq. (1966). Isoln from mycelium of the yeast Candida utilis Marimoto, Yamano, Biochem. Z. 340, 155 (1964). 

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