S -2-2- Diphenylphosphino phenyl-4-phenyloxazoline

MAP and its analogues considerably accelerate the Hartwig-Buchwald amination of aromatic and heteroaromatic halides and triflates (eq simiiai- acceleration is observed for Suzuki- 

Asymmetric induction is attained for selected Suzuki-Miyaura aryl-aryl couplings (eq 9). In this case, more electron-rich MAP with PCy2 group exhibits higher enantioselectivities (up to 87% ee) than its PPh2 counterpart (75% ee).  

Pyridine amide, derived from (5)-desmethyl-MAP, induces high enantioselectivity in Cu-catalyzed conjugate addition of Et2Zn to enones (eq 10).  

MAP-type ligands also catalyze asymmetric vinylation of ketone enolates (eq 11) with 56% ee for MAP (PPh2) and 90% ee for its PCy2 analogue (96% ee at —20°C).  

Purification impurities such as phosphine oxides, formed by air oxidation, can be removed by column chromatography on silica gel or, for crystalline derivatives, by recrystallization. 

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