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Rubredoxin native, structure

FIGURE 8.3 A hypothetical series of isomorphous heavy atom derivatives for a crystalline macromolecule, represented here by the polypeptide backbone of rubredoxin. (a) The apo-protein, stripped of its metal ion, provides native structure factors />, shown in vector and waveform on the right (b) the protein with its naturally bound iron atom and FHi, the first derivative structure factor (c) the protein with its iron plus an attached mercury atom, and the resultant structure factor Fm from the double derivative (d) a second multiply substituted derivative formed by attachment of a gold atom to the protein-iron complex. This last derivative is only marginally useful, however, since the reaction with gold also produces a modification in the tertiary structure of the protein (denoted by an arrow). Since this non-isomorphism is equivalent to introducing a nonnative structure factor contribution, the observed F s cannot be properly accounted for, and an erroneous heavy atom contribution / results. This final derivative will yield an inaccurate phase estimate 0v for the native protein. [Pg.177]

Fig. 7. (a) The idealized geometry of a model [Fe(SCH3)4] used for the extended Hiickel calculations and (b) schematic presentation of the proposed structure for [Fe(Z-cys-X-Y-cys-OMe)2] or native rubredoxin (21). [Pg.48]


See other pages where Rubredoxin native, structure is mentioned: [Pg.209]    [Pg.136]    [Pg.44]    [Pg.45]    [Pg.5539]    [Pg.178]    [Pg.180]    [Pg.195]    [Pg.81]    [Pg.349]    [Pg.5523]    [Pg.5538]    [Pg.208]    [Pg.212]   
See also in sourсe #XX -- [ Pg.47 ]




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Native structure

Rubredoxin

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