Rowland-Matin equation

Table 8.3 Predicting the impact of CYP inhibitors on new compounds values for [l], vo/Ki that can be inserted into the Rowland-Matin equation".

Thus, only if fmcYpvrere 0.5 would the AUG ratio double by GYP inhibition. However, as described earlier, the extent of clearance inhibition associated with enzyme inhibition actually depends upon the Ki value for the perpetrator. If a victim drug is metabolized by a single GYP enzyme, and if metabolism accounts for >50% of the victim drug s total clearance, then the AUG ratio arising from inhibition of that enzyme by a perpetrator is given by the Rowland-Matin equation ... 

In recent years, the utility of in vitro inhibition data to predict in vivo DDI was demonstrated. The underlying principles for this approach had been known for many years [99], but demonstration that these early concepts could be used practically in the prediction of clinical DDI was only obtained over the past few years. The principles can be applied for new compounds as the potential perpetrator of an interaction as well as the potential victim. The equation described by Rowland and Matin [99] forms the basis of this approach ... 

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