Rotating basket data

A liquid phase reaction, 2A => B, is conducted in a rotating basket of granular catalyst. The overall reaction rate is controlled by the rate of surface reaction but substance B is not adsorbed appreciably. The data are of... 

For gas-liquid-solid systems, studies on gas-liquid and liquid-solid mass transfer in basket reactors have been rather limited. For the rotating basket reactor, gas-liquid mass-transfer coefficient data are needed. Liquid-solid mass transfer has been studied by Teshima and Ohashi (1977), and their data are correlated by... 

Figure 10 Rotational (tangential) flow (UA) as a function of stirring rate (co) for paddle (filled circles) and basket (open circles) Mean SD position S2 approximately 1 cm above the paddle and midway between the paddle shaft and the wall of the dissolution vessel. (Please note that, in contrast to simulation techniques such as, for instance, computational fluid dynamics, these data are based on dissolution experiments.) Source Data from Ref. 10, UPE method.

The release tests were performed using the USP dissolution method (apparatus I) and utilized 1000 ml of pH 1.2 simulated gastric fluid (USP XXI) or pH 6.8 simulated intestinal fluid (USP XXI) without enzymes, equilibrated to 37°C and stirred with the basket rotating at 50 or 150 rev/ min. Drug concentrations were assayed by UV spectrophotometry at 255 nm. The experiments were continued until 100% dissolution was achieved. The release data were analysed to zero order, calculating the slope and intercept of the line. Each data point is the average of six individual determinations. In all cases the standard deviation was less than 9%. 

FIGURE 6.20. Test of the spinning basket adsorber. Overall rate coefficients for adsorption of propane on Linde 5A at 54 C were measured at several speeds of rotation in the presence of 500 Torr of either iQH,) or SFj. These species are both too large to penetrate the sieve. The uptake rate correlates with the gas phase molecular diffusivity indicating external mass transfer control. (Data of Taylor.< °>)... 

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