Roller compaction process densification

In contrast, increasing the gap width between the dry granulator rollers decreases the density of the compacted ribbon or briquette (also possible when other factors, such as feed rate or roll force, are changed). This reduced densification process results in a weaker binding of API to carrier excipients, and reduced overall granulation particle size distribution and increased bypass. 

The densification ratio in roller presses is limited to about 3 1. Therefore, material requiring the densifications assumed in Figs. 10.16a and c can not be processed with these machines in one pass. Possible remedies are to compact in two stages or to add... 

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