Role of Costimulatory Molecules

Murine studies suggest that CD28-B7 costimulation plays a critical role in the production of Th2 cytokines, the development of airway hyperresponsiveness. 

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The Bronchial Epithelium as a Regulator of Airway Inflammation 

The bronchial epithelium is increasingly being shown to play a dynamic role in regulating the inflammation, repair, and remodeling process of asthma. It is well established as an important source of mediators including arachidonic acid products (15-HETE, PGE2), nitric oxide (NO) endothelins, cytokines (IL-ip, IL-5, IL-6, IL-11, GM-CSF, IL-16, IL-18) (93-98), chemokines (IL-8, Gro-a, MCP-1, MCP-3, RANTES, MIP-la, MIP-2, eotaxin, and eotaxin-2), and molecules involved in inflammation and repair. 

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