Rodents homologue

Efficacy Epitope bound by the rodent homologue mAb may not express the same functional activity as the human IMBP. 

Stability Rodent homologue may not have sufficient stability to allow testing. 

Formulation May be impossible to formulate the rodent homologue at a high enough concentration to allow testing. 

When a biopharmaceutical is active only in primates (in some cases only in chimpanzees), an alternative approach is to create a rodent homologue (or... 

Fc functionality The rodent homologue may not express the same Fc functionality as the human biopharmaceutical... 

The standard carcinogenicity bioassays in rat and mouse are generally inappropriate The primate is often the only relevant species however, because of the small numbers of animals available and the lack of a broad dataset, testing of a rodent homologue might be an alternative U.S. not required to support phase I/II... 

Cloned and pharmacological 5-HTia receptors Rodent homologue of 5-HTib receptors A mouse homologue of h5-HTiB receptors... 

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