Rocuronium Carbamazepine

The duration of action of rocuronium can be reduced during long-term therapy with anticonvulsants (42). In one study the mean times to recovery of twitch height to 25% of baseline after rocuronium 0.6 mg/kg were 21 minutes in patients taking either carbamazepine or phe-nytoin versus 45 minutes in controls (43). It was suggested that the dose of rocuronium should be increased in patients taking antiepileptic drugs. 

Baraka A, Idriss N, Resistance to rocuronium in an epileptic patient on long-term carbamazepine therapy. Middle EastJAnesthesiol (1996) 13, 561-4. 

Spacek A, Neiger FX, Krenn CG, Hoerauf K, Kress HG. Rocuronium-induced neuromuscular block is affected by chronic carbamazepine therapy. Anesthesiology (1999) 90,109-12. 

Spacek A Neiger FX, Katz RL, Watkins WD, Spiss CK. Chronic carbamazepine therapy does not affect neuromuscular blockade by rocuronium. AnesthAnalg (1995) 80 (Suppl 2), S463,... 

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