RNA triplex

Fig. 3 Schematic representation of triplex form with chemical structures of base triplets of DNA and RNA triplexes. Reprinted from [80] with permission from Wiley InterScience...

Table 9 Various parameters for the interaction of berberine with DNA and RNA triplexes [221]...

Previous work has suggested that aminoglycoside specificity may occur in nucleic acid forms that display features characteristic of an A-type conformation (RNA triplex, DNA-RNA hybrid duplex,RNA duplex, DNA triplex, A-form DNA duplex, and DNA tetraplex ), rather than in naturally occurring RNA. However, conflicting results have been reported regarding the conformation of the triplex and of the Watson-Crick duplex within these triplexes. Both... 

The CD spectra of three triplexes are given in Fig. 7A. Two interesting conclusions were drawn from the spectra. First, the CD spectrum of the DNA triplex was much different from those of the RNA triplex and the one hybrid triplex that could be formed under the conditions (see legend to Fig. 4). This was consistent with molecular mechanics calculations that showed that DNA helices with alternating C" - G-C and T-A-T base triples can have predominately C2 -endo sugars, except for cytidines in the third strand. Second, the CD spectra of the other two triplexes were similar and A-like, indicating that the conformation of the hybrid triplex was close to that of the RNA triplex. The hybrid triplex had a d(AG),2... 

P. Carmona and M. Molina, Binding of oligonucleotides to a viral hairpin forming RNA triplexes with parallel G G C triplets, Nucleic Acids Res., 30 (2002) 1333-1337. 

Figure 27. Visualization of biomesogenic nucleic-acid selforganizations by molecular-resolving microscopies (top to bottom and left to right) nucleic acid strand patterns B-DNA and A-RNA duplexes, DNA/ RNA triplex, G-quadruplex, DNA/RNA-duplex/pro-tein-)3-sheet complexations STM and SFM-investi-gations of nucleic acid organizational behavior DNA-plasmid [74 c] RNA- and RNA/peptide-organiza-tions (U) (A) -duplexes (U) (A) (U) -tri-plexes (G) -quadruplexes, (L-Lys) /(U) (A) -com-plexes in 2D and 3D representation [7 a, 17, 18, 33 a, c, f, p, q, 75].

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