RNA interference methods

The analysis described above can be extended to other types of DNA damage and other TLS polymerases. This can be done using cells from mice in which specific polymerase genes were knocked-out or human cells in which the expression of specific polymerase genes was knocked-down using RNA interference methods. Using such an approach, it was found that Pol k is involved in the relatively accurate bypass of a benzo[a]pyrene (B[a]P)-guanine adduct (B[a]P-G),... 

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