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Rivastigmine

Because rivastigmine is not hepatically metabolized, pharmacokinetic cytochrome P450-related drug interactions are not expected. However, the previously discussed pharmacodynamic interactions associated with other cholinesterase inhibitors may occur with rivastigmine as well. [Pg.209]

Donepezil has the advantage of once-daily administration and appears to be better tolerated than tacrine. Tacrine is particularly harmful to the liver. The new dragp rivastigmine and galantamine, like the other two, are effective in treating mild-to-moderate dementia of AD. [Pg.305]

CijHjjNO 58574-44-0) see Tolpropamine ( )-3-[l-(dimethylamino)ethyI]phenol (C,( H 5N0 105601-04-5) see Rivastigmine [2-(dimethylamino)ethyI](phenyImethyl)propanedioicacid diethyl ester... [Pg.2361]

Corey-Bloom J, Anand R, Veach J, for the ENA 713 B352 Study Group (1998). A randomised trial evaluating the efficacy and safety of ENA 713 (rivastigmine tartrate), a new acetylcholinesterase inhibitor, in patients with mild and moderately severe Alzheimer s disease. IntJGeriatrPsychopharmacolX, 55-65. [Pg.86]

NICE] National Institute for Clinical Effectiveness (2001). Guidanee on the Use of Donepezil, Rivastigmine and Galantamine far the Treatment of Alzheimer s Disease. Technology Assessment Guidance No. 19. London ... [Pg.87]

Rivastigmine is approved for the treatment of mild to moderate dementia of AD at an initial dose of 1.5 mg twice daily if this dose is tolerated for at least 2 weeks, then the dose can be increased to 3 mg twice daily. Increases to 4.5 mg twice daily and 6 mg twice daily should be attempted only after at least 2 weeks at the previous dose. Tolerability and absorption are improved when the dose is given with food. [Pg.519]

Data from product Information for tacrine, donepezil, rivastigmine, galantamine, and memantine.34-38... [Pg.520]

Data from Product Information tacrine, donepezil, galantamine, memantine, and rivastigmine.34-38... [Pg.520]

Anticholinesterase A drug that inhibits the enzyme acetylcholinesterase, which normally inactivates acetylcholine at the synapse. The effect of an anticholinesterase (or cholinesterase inhibitor) is thus to prolong the duration of action of the neurotransmitter. An example is rivastigmine, used in the treatment of Alzheimer s disease. [Pg.237]

Rivastigmine An anticholinesterase used to treat Alzheimer s disease. [Pg.248]

Wilkinson D, Passmore P, Bullock R, Hopker SW, Smith R, Potocnik FCV, Maud CM, Engelbrecht I, Ieni JR and Bahra RS (2002). A multinational, randomized, 12-week comparative study of donepezil and rivastigmine in patients with mild to moderate Alzheimer s disease. International Journal of Clinical Practice, 56, 441-446. [Pg.287]

No direct comparative trials have assessed the effectiveness of one agent over another. Donepezil, rivastigmine, and galantamine are indicated in mild to moderate AD, while donepezil is also indicated in severe AD. [Pg.743]

Rivastigmine has central activity at acetylcholinesterase and butyrylcho-linesterase sites, but low activity at these sites in the periphery. [Pg.744]

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Rivastigmin

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