Rituximab dosage

The rituximab dosage is 375 mg/m2 weekly for 4 weeks. Maintenance schedules include 375 mg/m2 weekly for 4 weeks every 6 months for 2 years or 375 mg/m2 every 2 to 3 months for 1 to 2 years. Maintenance rituximab significantly prolongs progression-free and overall survival as compared with observation or initiation of rituximab at the time of disease progression. 

In the future, perhaps, a lower standard dosage, and/or a less frequent schedule of rituximab, can become established for longer-term use, espedaUy for older dysimmune patients. 

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