Ring-fused tetrahydroazepines

Scheme 34 Enantioselective Au-catalyzed selective formation of ring-fused tetrahydroazepines...

Zhang and coworkers reported two divergent redoxisomerization pathways for yne-enones 151 to afford ring-fused tetrahydroquinolines and tetrahy-droazepines. Product selectivity depends on whether a carbophilic or oxophilic Lewis acid was used. Ring-fused tetrahydroazepines 152 could be obtained in moderate to excellent yields via the carbophihc gold(I)-catalyzed domino reaction under the mild conditions (Scheme 12.66) [70]. 

Scheme 12.66 Au-catalyzed synthesis of ring-fused tetrahydroazepines. 1 2.6.5...

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