Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Ring-closing alkyne metathesis epothilones

Ring-closing alkyne metathesis (RCAM) leads to alkyne macrocydes in excellent yields [36]. When combined with hydrogenation using a Lindlar-type catalyst, it is a convenient pathway to macrocydic Z-cydoalkenes. Fiirstner and coworkers utilized this strategy for numerous total syntheses of natural products [37], epothilone A being one of them [38]. [Pg.45]

Scheme 28. FOrstner s total synthesis of epothilone C (59) using ring-closing alkyne metathesis with molybdenum-based catalyst 94. ... Scheme 28. FOrstner s total synthesis of epothilone C (59) using ring-closing alkyne metathesis with molybdenum-based catalyst 94. ...
See other pages where Ring-closing alkyne metathesis epothilones is mentioned: [Pg.242]    [Pg.319]    [Pg.44]    [Pg.705]    [Pg.206]    [Pg.1039]    [Pg.475]    [Pg.364]   


SEARCH



Alkynes metathesis

Ring metathesis

Ring-closed

Ring-closing

Ring-closing alkyne

Ring-closing alkyne metathesi

Ring-closing metatheses

Ring-closing metathesi

© 2024 chempedia.info