Rimocidinolide synthesis

Rimocidinolide synthesis 162 Ring contraction 12 Ru (see Grubbs Reaction)... 

Enantioselective Synthesis of the Polyene Antibiotic Aglycone Rimocidinolide Methyl Ester... 

The complex polyene macrolide antibiotics are clinically effective as antifungal agents. Scott Rychnovsky of the University of California at Irvine has reported (Angew. Chem. hit. Ed. 2004,43, 2822) the first synthesis of rimocidinolide methyl ester 4, the aglycone of rimocidin 1. The key step in the synthesis is the condensation of the aldehyde 2 with the phosphonate 3, leading to 4. 

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See also in sourсe #XX -- [ ]

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