Zolpidem rifampicin

Rifampicin, and presumably other enzyme inducers, reduces concentrations of zolpidem, zopiclone, and buspirone (SEDA-22, 42). Drugs that are solely glucuroni-dated (lorazepam, oxazepam, and temazepam) are not affected. 

Rifampicin, and presumably other CYP3A inducers, reduces concentrations of zolpidem (SEDA-22, 42). 

ZALEPLON, ZOLPIDEM, ZOPICLONE ANTIBIOTICS-RIFAMPICIN -l levels of these hypnotics Induction of CYP3A4-mediated metabolism Watch for poor response to these agents... 

Zaleplon, zolpidem and zopiclone are metabolised by several cytochrome CYP450 isoenzymes and it has been suggested that because of this, other drugs which affect a particular isoenzyme such as CYP3A4, may have less effect on their metabolism. However, their pharmacokinetics are affected by potent inducers such as rifampicin and by inhibitors such as the azole antifungals. Buspirone undergoes CYP3A4-mediated metabolism in the liver. 

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See also in sourсe #XX -- [ ]

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