Rifampicin Carvedilol

BETA-BLOCKERS RIFAMPICIN L plasma concentrations and efficacy of bisoprolol, carvedilol, celiprolol, metoprolol and propanolol Rifampicin induces hepatic enzymes (e.g. CYP2C19), which t metabolism of the beta-blockers in addition, it may also t P-gp expression Monitor PR and BP watch for poor response to beta-blockers... 

Rifampicin increases the clearance of bisoprolol, carvedilol, celiprolol, metoproioi, propranolol, tertatolol and talinolol, and reduces their serum levels. The extent to which this reduces the effects of these beta blockers is uncertain, but it is probably small. Similar effects have been seen when atenolol is given with rifampicin, but a case report su ests that occasional the effects may be of clinical relevance. 

Rifampicin 600 mg daily for 12 days caused a 60% decrease in the maximum serum levels and the AUC of carvedilol. ... 

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