Ribosome hopping

Ribosomal shifts can occur over a considerable distance without intermediate steps, a phenomenon known as ribosomal hopping (124). An extreme case of hopping is the skip of 50 nt that separate codon 46 from codon 47 in the mature message of T4 topoisomerase subunit gene 60 (12). The elements contributing to the skip are presumed to be located both at the coding gap which contains a pseudoknot and at the nascent, 46-aa peptide which precedes the interruption. 

Pillay, M. and Kenny, S. T. 1996. Structure and inheritance of ribosomal DNA variants in cultivated and wild hop Humulus lupulus L. Theor. Appl. Gen. 93 333-340. 

An extreme example of translational bypassing occurs in the translation of the bacteriophage T4 gene 60 (13). The ribosome reads the first 46 codons of the mRNA, pauses at a UAG stop codon, hops over 47 nucleotides (a 50-nucleotide coding gap), and resumes translation. This bypass requires matched codons. The peptidyl-tRNA pairs first with one codon, slips, and then pairs with the matching codon, which results in only one... 

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