Ribosome antibiotic complexes crystal structures

Table 1 Crystal structures of ribosome antibiotic complexes in Figure 2...

Rational efforts to design new antibiotics that target the ribosome became feasible when the crystal structures of both ribosomal subunits were solved at atomic resolution in 2000 [1-3]. Since then, structures of about 20 different antibiotics bound to ribosomes have been published (Tab. 4.1) [4—12]. These structures of antibiotic/ribosomal complexes provide insights into the mechanisms by which antibiotics inhibit protein synthesis and by which mutations confer resistance. Thus, a sound basis now exists for designing new antibiotics that may circumvent resistance. 

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