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Ribose sugar modification

Figure 9.4. Secondary structure of the 24-mer VPF/VEGF modified aptamcr. Pyrimidines (Y) all contained 2 -fluoro-2 -deoxy modifications, purines (R) with 2 -methoxy-2 -deoxy modifications are boxed purines (R) with unmodified ribose sugar residues are circled. The dissociation constant of the aptam-er/protein complex was 190 pM. Figure 9.4. Secondary structure of the 24-mer VPF/VEGF modified aptamcr. Pyrimidines (Y) all contained 2 -fluoro-2 -deoxy modifications, purines (R) with 2 -methoxy-2 -deoxy modifications are boxed purines (R) with unmodified ribose sugar residues are circled. The dissociation constant of the aptam-er/protein complex was 190 pM.
Imanishi, Takeshi Obika, Satoshi Sugar modification Bridged artificial riboses, 3, 5 -linkage W09839352 1998... [Pg.331]

Nippon Shinyaku Co., Ltd., Sugar modification l -Methyl riboses WO9618640 1996... [Pg.331]

FIGURE 4.1 Chemical modifications to ribose sugar or phosphate linkages. BNA, bridged nucleic acid LNA, locked nucleic acid PMO, phosphorodiamidate morpholino oligomer. [Pg.43]

From L-arabinose, carba-sugars of the a-D-gluco and h-altro types were prepared from D-arabinose, carba-a-L-mannopyranose from D-ribose, that of the fi-L-manno modification from D-xylose, those of the -L-gluco and a-D-altro forms and, from D-glucose, those of the P-L-allo a-L-... [Pg.41]


See other pages where Ribose sugar modification is mentioned: [Pg.712]    [Pg.370]    [Pg.189]    [Pg.712]    [Pg.370]    [Pg.189]    [Pg.97]    [Pg.451]    [Pg.304]    [Pg.228]    [Pg.540]    [Pg.115]    [Pg.447]    [Pg.451]    [Pg.492]    [Pg.27]    [Pg.28]    [Pg.270]    [Pg.684]    [Pg.647]    [Pg.61]    [Pg.334]    [Pg.1064]    [Pg.271]    [Pg.148]    [Pg.9]    [Pg.157]    [Pg.294]    [Pg.128]    [Pg.247]    [Pg.228]    [Pg.533]    [Pg.965]    [Pg.55]    [Pg.85]    [Pg.351]    [Pg.28]    [Pg.29]    [Pg.29]    [Pg.30]    [Pg.33]    [Pg.34]    [Pg.499]    [Pg.137]    [Pg.533]    [Pg.322]    [Pg.171]   
See also in sourсe #XX -- [ Pg.43 ]




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