Manganese ribonucleotide reductase

Scheme 7. A partial proposed mechanism for the functioning of iron ribonucleotide reductase. Manganese ribonucleotide reductase may function in a similar manner. [Adapted with permission from (113) and (111). Copyright 1994, Current Biology Publishers, and Copyright 1994 Marcel-Dekker, Inc., respectively.]...

Tyrosine-bound manganese purple manganese acid phosphatase and ribonucleotide reductase 587... 

Although an X-ray crystal structure of MnRR has not been solved to date, a structure with Mn substituted into the iron ribonucleotide reductase has been reported (Fig. 6) (124). In this case, the two man-ganese(III) ions were bridged by two carboxylates from protein residues, but without the oxo bridge postulated for the active Fe1 form of the FeRR enzyme. This inactive enzyme with manganese was proposed as a model for the inactive Fe form of the iron enzyme and is... 

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