Ribonucleic acids cleavage

The ribonucleases are a class of enzymes catalyzing the hydrolytic cleavage of ribonucleic acids. Although such activity can be demonstrated in almost all tissues both plant and animal, relatively few of... 

Construction of reagents for directed cleavage of ribonucleic acids 01UK562. 

D-Ribonic acid, esters D-psicosides from, 272 Ribonucleic acid. See RNA Ring cleavage electrocyclic (cycloreversion) [l+l-i- 2]- double CO elimination, 78, 339 [1 + 4]- CO elimination, 337 S02 elimination, 80,153 [2 + 2]- benzene elimination, 331, 332-333 prismane opening, 330-331 rhodium( 1 + )-catalysed, 332 thermal, 79-80... 

Fig. 26. Cleavage of ribonucleic acid by ribonuclease (vertical lines labeled R) and snake venom 5 -phosphodiesterase (broken lines labeled V). P represents phosphate linking 3 and 5 positions of adjacent nucleotides.

Ribonucleic acid is thought to possess a highly branched structure. Cleavage about a branch point in the manner illustrated in (VIII) would give the pyrimidine nucleoside diphosphates discussed above. Ribonucleic acid also contains a number of phospho-monoester end groups which are susceptible to acid prostatic phosphatase and certain other monoesterases. A great deal has been learned of ribonucleic acid structure... 

This compound has been isolated after subjecting yeast ribonucleic acid to brief acid hydrolysis. When it is treated with alkali there is cleavage at (1), with the formation and subsequent hydrolysis of a cyclic anhydride of guanylic acid. The final products are guanosine-2 -phosphate, guanosine-3 -phosphate, and cytidine-3 -phosphate. The last two would be split by 3-nucleotidase from barley. 

Two intermediates (64 R=MMTr or pixyl) have been synthesised and used to make branched ribonucleic acids, since they permit extension in all three directions. 132 phosphoramidltes of type (65) have been prepared, where the base is also protected by a group removable by reductive cleavage. 133... 

Scheme 5.27 Main-chain cleavage of ribonucleic acid induced by OH-radical attack at the 4 -position.

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