Riboflavin vitamin actions/effects

Other fractions of the vitamin B complex have also been tested for their effect on the survival of young adrenalectomized rats, and it was found that biotin was as effective as pantothenate (Ralli and Dumm, 1952). This is interesting in view of the previous discussion of the interrelation of biotin and pantothenic acid (see Section V.b). In this same series of experiments it was observed that large doses of pyridoxine were toxic to adrenalectomized rats when given after a period of pantothenate deficiency. Thiamine and riboflavin had no influence on survival, but folic acid and vitamin Bu resulted in a moderate improvement. These observations emphasize the interaction of vitamins under various nutritional situations in relation to hormone action. 

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