Ribitol 1,5-dideoxy

Six sugar-mimicking alkaloids such as 1-deoxynorjirimycin (4), 1,4-dideoxy-l,4-imino-D-ribitol (8), 2,5-imino-l,2,5-trideoxy-L-glucitol (9),... 

Pyrimidine nucleoside hydrolase YeiK from E. coli in complex (PDB 3MKN) with l-(3,4-diaminophenyl)-l,4-dideoxy-l,4-imino-D-ribitol (175, 76 pM Scheme 48)... 

J. Di, B. Rajanikanth, and W. A. Szarek, Fluorinated l,5-dideoxy-l,5-iminoalditols Synthesis of l,5,6-trideoxy-6-fluoro-l,5-imino-D-glucitol (l,6-dideoxy-6-fluoronojirimycin) and 1,4,5-trideoxy-4-fluoro-l,5-imino-D-ribitol (l,2,5-trideoxy-2-fluoro-l,5-imino-L-ribitol), J. Chem. Soc., Perkin Trans. 1 (1992)2151-2152. 

N-Ribohydrolases have been found to be involved in novel pathways of purine salvage in protozoan parasites as well as in nucleic acid repair, and exhibit other interesting biological activities [178]. In order to investigate the molecular electrostatic potential surface of the enzyme from the trypanosome Crithidia fasci-culata, several l,4-dideoxy-l,4-imino-D-ribitol derivatives were synthesized as nucleoside analogues and their inhibitory powers were tested [179,180]. In the course of this work, l,4-dideoxy-l,4-imino-l(S)-phenyl-D-ribitol (97) was found to inhibit this enzyme with K 30 nmol/1. 

During the 1950 s and early 1960 s, J. K. and his coworkers achieved new syntheses of a number of simple sugars. These included D-taga-tose and D-psicose, 5,6-dideoxy-D-xt//o- and - .-arabino-hexose, derivatives of D-ribitol, 5-S-ethyl-5-thio-D-threo-2-pentulose, u-glycero-D-... 

A series of interesting derivatives was prepared21,69 starting from phosphoranes having maleimido, amido, and nitryl functions. These products were 2,4 3,5-di-0-benzylidene-l-deoxy-l-(2,5-dioxo-3-pyr-rolylidene)-D-ribitol (99a), its N-phenyl derivative (99b), 2,4-0-benzylidene-1 -deoxy- l-(2,5-dioxo-3-pyrrolylidene)-D-ribitol (99c), 4,6 5,7-di-0-benzylidene-2,3-dideoxy-D-nbo-hept-2-enonamide (100), 2,3-dideoxy-D-giuco-oct-2-enonamide 4,5,6,7,8-pentaacetate (101), 4,6 5,7-di-0 - benzylidene - 2,3 - dideoxy - D - ribo-hept-2-enononitrile (102), and 2,3-dideoxy-D-g(uco-oct-2-enononitrile 4,5,6,7,8-pentaacetate (103). Derivatives 99a-99c were prepared for use in the... 

Acetamido-5-deoxy-D-threo-pentulose and 5-acetamido-5-deoxy-L-erythro-pentulose (204) are obtainable by the bacterial oxidation of 1-acetamido-l-deoxy-D-arabinitol and 1-acetamido-l-deoxy-D-ribitol, respectively. Both ketoses are crystalline, and show a strong carbonyl vibration in their infrared spectra. Accordingly, they exist in the acyclic form. Their isopropylidene acetals are likewise acyclic. Furthermore, 5-acetamido-5,6-dideoxy-L-xylo-hexulose (205), obtainable by bacterial oxidation, shows a great tendency to assume the acyclic structure. 5-Acetamido-5-deoxy-L-xi/io-hexulose (206) may be obtained by the bacterial oxidation of 2-acetamido-2-deoxy-D-glucitol it assumes, exclusively, the sterically more-favored pyranose form. ... 

Dideoxy-l, 4-imino-D-ribitol Moms alba (Moraceae) roots"... 

Dideoxy-1,4-iniino-D-ribitol weak inhibitor of a-glucosidase ... 

Synthesis from D-gulonolactone Synthesis of l,4-dideoxy-l,4-imino-D-ribitol... 

Asano, N. et al., Carbohydr. Res., 1994, 2, 235 259, 243 (l,4-Dideoxy-l,4-imino-2-0- -D-glucopyranosyl-D-arabinitol 1,4-Dideoxy-1,4-imino-D-ribitol)... 

Dideoxy-D-erythto-pentitol, PCI. 1,2-Dideoxy-D-ribitol. 1,2-Dideoxy-D-arabini-tol... 

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