Ribavirin Theophylline

Peg Interferon Alfa 2b (PEG-Intron) [Antiviral/ Immunomodulator] WARNING Can cause or aggravate fatal or life-threatening neuropsychiatric, autoimmune, ischemic, and infectious disord s. Monitor pts closely Uses Rx Hep C Action Immune modulation Dose 1 mcg/kg/wk SQ 1.5 mcg/kg/wk combined w/ ribavirin Caution [C, X if used w/ ribavirin /-] w/ Hx psychiatric Contra Autoimmune H, decompensated Uvct Dz, hemoglobinopathy Disp Vials 50, 80, 120, 150 mcg/0.5 mL Redipen 50, 80,120,150 mcg/5 mL reconstitute w/ 0.7 mL w/ sterile water SE D ession, insomnia, suicidal behavior, GI upset, neutropenia, thrombocytopenia, alopecia, pruritus Interactions t Myelosuppression W/ antineoplastics t effects OF doxorubicin, theophylline t neurotox W7 vinblastine EMS See Peg Interf on Alfa-2a may cause flu-like Sxs... 

Oral ribavirin 200 mg every 6 hours had no effect on the plasma theophylline levels of 13 healthy subjects given immediate or sustained-release aminophylline. Similarly, ribavirin 10 mg/kg daily did not affect the plasma theophylline levels in 6 children with influenza and asthma. No special precautions seem necessary on concurrent use. 

Fraschini F, Scaglione F, Maiema G, Cogo R, Furcolo F, Gattei R, Borghi C, Palazzini E. Ribavirin influence on theophylline plasma levels in adult and children. IntJ CUn Pharmacol Ther Toxicol 9ZZ) 26,30-2. 

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