Rh-Catalyzed Synthesis of Oxygen-Containing Heterocycles

In 2014, the Glorius group developed a Rh(III)-catalyzed annulation of benzamides with 1,3-diynes to the synthesis of bisheterocycles (Scheme 6.28) [44]. Selective monoannulation was realized under room temperature and a lower catalyst loading. Oxygen-containing heterocycles were prepared by subsequent multiple annulation with acrylic acid and o-vinylphenol by alkenyl C-H activation. 

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