Reversal of desensitization

Several reports indicate that LH induced desensitization can be reversed. Reversal of LH-induced desensitization of adenylate cyclase in testis Leydig cells has been found to be dependent on the time and concentration of LH used [78] at low physiological concentrations of LH the desensitization was completely reversed during incubation of cells for 2 h in the absence of further hormone. With higher concentrations of LH however, the cells remained unresponsive to further challenges with the hormone over the same time period. 

Addition of phosphoprotein phosphatase can reverse LH induced desensitization of follicular adenylate cyclase [73]. Addition of human erythrocyte membranes to plasma membranes from LH desensitized Leydig tumour cells restores their response to LH [79], 

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