Retrosynthetic Analysis for Lipid II

Following the lipid I analogy, we would introduce the lipid diphosphate at a late stage in the synthesis that would leave only a global deprotection as a final step.26 Disconnecting the diphosphate linkage provided the first retrosynthetic intermediates, disaccharyl pentapeptide 

27 and the commercially available undecaprenyl monophosphate 8. Precursor 27 would be prepared by coupling of disaccharyl monopeptide 

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