Retro-claisenase

Desymmetrization of l-Methylbicyclo[3.3.0]octane-2,8-dione by tbe Retro-claisenase 6-Oxo Camphor Hydrolase... 

A range of symmetrical bicyclic /3-diketones can be converted to 2,3-disubstituted cycloalkanones in high yield with high diastereomeric and enantiomeric excess using a cell-free preparation of a retro-Claisenase enzyme, or /3-diketone hydrolase, the gene for which has been heterologously expressed in Escherichia coli. ... 

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