Retinal pigment epithelium uptake

Wang, N and Anderson, RE, 1993. Transport of 22 6n-3 in the plasma and uptake into retinal pigment epithelium and retina. Exp Eye Res 57, 225-233. 

Miyamoto, Y., et al. 1991. Taurine uptake in apical membrane vesicles from the bovine retinal pigment epithelium. Invest Ophthalmol Vis Sci 32 2542. 

Although the precise role of taurine In retina Is not completely known there Is evidence that It can play an Inhibitory transmitter pole (16, 17) since It Is able to affect potassium and calcium fluxes at the Ionic membrane level (18-20), At the light of these findings It Is easily Interpreted the functional Inhibitory role of taurine In experiments In which from perfused chick and rat retina preloaded with 35S-taurlne light flashes enhance endogenous and labeled taurine release (21,22), Taurine Is the most potent amino acid able to reversibly abolish electroretinogram b wave (23-25) as well as to depress several neuronal populations from cerebral cortex, subcortical areas and spinal cord (26-29), In addition a specific uptake system has been described to occur In rat retina (30, 31) as well as In retinal pigment epithelium (32) and In slices and synaptosome preparations from various areas of the brain (33, 34),... 

---