Retina pupillary response

Van Gelder Again, how these different pigments play into the different output pathways is not clear. For example, in the pupillary light responsiveness we see a marked diminution in pupillary response comparing wild-type to rd rd mice. We see no diminution in phase-shifting response for entrainment in these animals. This means that, for pupillary responses, 90% of the response is driven by the outer retina, whereas for circadian responses it may be that none or only a small fraction is normally mediated by the outer retina. 

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