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Retention times, linear analogs

Retention in ThFFF is directly proportional to the temperature drop (AT) across the channel (see Eq. 1). The linear relationship between and AT holds even for moderate levels of retention (VVV° > 3). Having a predictable dependence of retention on AT means that AT can be efficiently tuned to optimize the trade-off between resolution and analysis time for each application. AT can also be varied over the course of a separation to resolve samples of extreme polydispersity in the most efficient manner. Decreasing AT over the course of a separation is analogous to temperature programing in gas chromatography or solvent programing in reversed-phase HPLC. [Pg.2309]


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