Retention times and structures

TABLE 2 HPLC/UV Retention Times and Structures of EMD 122 347 (Glycoprotein lib/l I la Antagonist) and Related Impurities... [Pg.359]

The use of GC-MS or LC-MS-MS instead of GC-TEA provides higher throughput with analyte-specific detection based on both retention time and structurally specific analyte fragmentation information. The identification is usually based on the detection of several dominant ions characteristic of the nitrosamines, such as fragments of m/z = 75, 74, 59, 42, 41 for NDMA and m/z = 103, 102, 71, 57, 56, 42, 41 for Al-nitrosodiethylamine. The ion ratio of the primary ion (m/z = 74) to the secondary ion (m/z — 42) is generally used to confirm the presence/absence of NDMA in complex samples. ... [Pg.443]

High pH anion exchange chromatography (HPAEC) has been applied to the separation of neutral V-linked oligosaccharides, oligosaccharides derivatized by p-nitrobenzylhydroxylamine and various D-mannose derivatives. In the last case the relationship between retention times and structure was examined. ... [Pg.351]

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