Resveratrol INDEX

Figure 9.3 Inhibition of intimal hyperplasia by resveratrol in rabbits subjected to endothelial injury by denudation. Groups of eight New Zealand white rabbits, weighting 2.2 to 3.6 kg, were assigned randomly to control (untreated) (M), low (2 mg/kg/d) (L), and high dose (4 mg/kg/d) (H) resveratrol treatment, which was administered intragastrically for 5 weeks beginning 1 week before surgery. A 2-cm segment of injured iliac artery was excised, fixed in 4% paraformalin, embedded in paraffin, and sectioned at5-mm intervals from the proximal to the distal end. Representative sections were stained with hematoxylin/eosin. The external and internal elastic lamina were manually identified. Intimal proliferation index (IPI) was defined as the ratio of intimal area to [intimal+medial] area relative luminal area (RLA) was defined as the ratio of luminal area to [luminal+intimal+medial] area.

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