Resveratrol and Apoptosis

To explore the contribution of resveratrol to the proliferation and apoptosis of lens epithelial cells, the thiazolyl tetrazolium (MTT) assay was conducted [47]. The stilbene effects on the proliferation of lens epithelial cells cultured with different concentrations of this compound were measured. HE staining, transmission electron microscopy (TEM), TUNEL fluorescence staining, and the aimexin V assay 

OCHa 0CH3 HaCO r OCHa 0CH3 HaCO cjx OCH3 

The experimental results showed that the proapoptotic effects of R3 against tumor cells were independent of their p53 status. 

The mechanism of action of resveratrol in imatinib-sensitive (IM-S) and -resistant (IM-R) CML cell lines was investigated [58]. Resveratrol induced the loss of viability and apoptosis in IM-S and IM-R in a time- and dose-dependent fashion. Inhibition of 

Resveratrol (2.1) was used as the prototype compound to synthesize trans- and c/s-stilbene analogues. The compounds are grouped according to their cytotoxicity. The IC50 for compounds in each group is Croup 1, 100pM Croup 2, 20-80pM Croup 3, 2-lOpM  

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