Restructured ring systems

An interesting example of a restructured ring system was designed by Meyer et al. for the design of 5-methoxy-hexahydro-l//-benz[f]isoindole as a surrogate of the very frequently used ort/to-methoxy-A-arylpiperazine. It led... 

Restructuring ring systems. Among the above-mentioned molecular variations on ring systems, some can be used simultaneously. Thus the splitting of the benzimidazole heterocycle in the anthelmintic thiabendazole and the concomitant association of the two five-membered rings yields tetramizole (Fig. 14.26). One of the two enantiomers of tetramizole, the L-(—)-form, or levamizole, is also a potent anthelmintic. 

An interesting example of a restructured ring system was designed by Meyer et for the design of 2-methoxybenz-... 

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