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Restriction enzymes binding affinity

Typically, because of mechanistic requirements the lyases are highly specific for the nucleophilic donor component. This includes the necessity for a reasonably high substrate affinity as well as the general difficulty of binding and anchoring a rather small molecule in a fashion that restricts solvent access to the carb-anionic site after deprotonation and shields one enantiotopical face of the nucleophile in order to secure correct diastereofacial discrimination (Figs. 2 and 3) [51]. Usually, approach of the aldol acceptor to the enzyme-bound nucleophile occurs stereospecifically following an overall retention mechanism,... [Pg.103]

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See also in sourсe #XX -- [ Pg.263 , Pg.264 , Pg.265 ]



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Binding affinity

Enzyme affinity

Enzymes binding

Restricted enzyme

Restriction enzym

Restriction enzymes

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