Restricting Peptide Conformation through Cyclization

While proteinic ligands are typically endowed with high affinity and specificity for their target, attempts to reconstitute these activities with the peptidic fragment 

High yield for 8 carbon linker using homochiral crosslinking amino acids 

High yield for 11 carbon linker using heterochiral crosslinking amino acids 

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Figure 13.8 Restricting peptide conformation through cyclization.

Toniolo C. Conformationally restricted peptides through short-range cyclizations. Int. J. Pept. Protein Res. 1990 35 287-300. 

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