Response Modifiers as Antineoplastic Agents

Title Polycyclic Compounds Exhibiting Antitumor Activities 

Invention Significance Although farnesyl and geranylgeranyl transferase 

Preparation of 3-methoxy-6-(2- methyl-[2-(3-methoxy-7-oxo-7H-5,9-diaza-benzo[c]fluoren-6-ylamino)-ethyl]-amino -ethylamino)-5,9-diaza-benzo[c]fluoren-7-one 

A mixture consisting of 6-chloro-3-methoxy-5,9-diaza-benzo[c]fluoren-7-one (21 mg), A-methyl-2,2 -diaminodiethylamine (3.3 mg), and K2C03 (10 mg) was suspended in 0.5 ml DMF and stirred 13 hours at 90°C, then concentrated. The residue was purified by chromatography on silica gel using CH2Cl2/methyl alcohol, 

and CH2Cl2/methyl alcohol/25% NH4OH, 30 1 0.4, and the product isolated as a reddish powder. 

---

Vm. Cervical Cancer Immune Response Modifiers as Antineoplastic Agents... 

---