Resource Optimization Technique field resources

Since we wished to optimize this series with a minimal expenditure of our synthetic resources, the sequential simplex technique (SSO) was selected (11,12). This strategy is very resource efficient, requiring only n + 1 compounds to start the optimization, where n is the number of physiochemical parameters used to describe the characteristics of a substituent. We selected pi to account for lipophilicity and field (F) and resonance (R) were used to describe the electronic effects of each substituent (14). Verloop s Sterimol parameters (H), minimum van der Waals radius (B] ) and length (L) were selected to describe the size of the substituent. Using cluster analysis, we selected a set of six substituents that cover physiochemical parameter space well (15). These are-listed in Figure 6. 

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