Resonant mirror biosensing

Resonant mirror biosensing (surface plasmon resonance)... 

Resonant mirror biosensing is a superb technique for the analysis of receptor-ligand interactions in real time. Therefore, association constants may be determined directly from kinetic constants This may sound a little strange, but let us consider the binding equilibrium shown in Scheme 7.4. By definition, equilibrium is reached when the rate of association (M s ) of receptor with ligand is equalled by the rate of receptor-ligand complex dissociation diss (s )- Hence... 

Obviously, an equivalent expression could be written for the reverse situation when the ligand L is immobilised (imm) instead. In either case, to a hrst approximation the association constant written in Equation (7.57) is said to be essentially identical to the constant dehned in Equation (7.58). This is important, since immobilisation of receptor R (or ligand L) to a solid phase resin is central to resonant mirror biosensing. 

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