Resolution per unit of time

The chiral columns used for liquid chromatography may also be used for supercritical fluid chromatography (SFC). SFC offers important advantages over HPLC and GC in the separation of enantiomers. First, SFC provides a higher resolution per unit of time than does LC, because the diffusion rates in the mobile phase and linear velocities are higher. Second, SFC chromatography is carried out at temperatures well below those used in GC. LC and GC detectors, such as FID (flame iruiized detectors) and mass spectrometry (MS), may also be applied to SFC (Chamberlain et al. 1998). 

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