Resolution, of racemic modification

Figure 10.4 A Schematic representation of the use of diastereoisomers in the resolution of racemic modifications...

The determination of the enantiometric purity of optically active carboxylic acids and amino acids is important not only for an evaluation of their asymmetric syntheses, but optical resolution of racemic modifications of chiral carboxylic acid derivatives and chiral amino acids is also industrially important. A separation on both an analytical and a preparative scale of the racemically modfied and commercially available carboxylic acids 21a-24a and amino acids 25a-27a was attempted by utilizing (4/ ,5S)-MPOT (5). The condensations between 5 and the carboxylic and amino acids 21a-27a were carried out as usual to afford the corresponding 3-acyl-(4/ ,5S)-MPOT derivatives 21b-27b. Their analytical separation was readily achieved by HPLC. H-NMR techniques can also be useful for the analysis of the diastereoisomeric ratio of amides 21b-27b. 

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See also in sourсe #XX -- [ , , ]

See also in sourсe #XX -- [ , , ]

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