Resistance mechanisms not involving kinase domain mutations

5 Resistance mechanisms not involving kinase domain mutations 

Kinase domain mutations are not the only mechanism that may lead to drug resistance. As noted in Section 5.2, several additional mechanisms have been identified by which cells can escape or mitigate the effect of dosing with imatinib. In several other cells, resistance has been traced to one or several factors associated with changes in signaling or metabolic pathways. Several examples are highlighted in this section, in which resistance has been traced to one or several factors that do not involve kinase domain mutations. 

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