Resistance and Telomere Component Expression

The second strategy was to obtain 12459-resistant A549 clones after shortterm exposure to high concentrations of the ligand, together with EMS 

For these two strategies, the up-regulation of MDR efflux was not involved and our results indicated that these resistant models displayed interesting differences for the short- and long-term effects of 12459. 

Owing to the link established between hTERT and the protection of the single-stranded G-overhang in normal cells and because of the role of the shelterin complex that includes both single- and double-stranded telomerebinding proteins to protect telomere extremities, a careful examination of this 

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